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Old 01-02-2002, 11:39 AM
tremor tremor is offline
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Join Date: Aug 2001
Location: Stratford, CT
Posts: 1,476
World Health Organization

There doesn't appear to be any documented cases of HUMAN carconogenic relationship. Only Rats, which have to consume rediculous quantities to exhibit symptoms. If I'm wrong, I guess skin cancer is my fate!
Seriously, PPE is allways the way to go!
___Steve_______________________________________

No. 183: Chlorothalonil

1996, 145 pages [E, with summaries in F, S] ISBN 92 4 157183 7 Sw.fr. 35.-/US $31.50; in developing countries: Sw.fr. 24.50 Order no. 1160183

Evaluates the risks to human health and the environment posed by exposure to chlorothalonil, a fungicide widely used in agriculture to protect pome and stone fruit, citrus, currants, berries, bananas, tomatoes, green vegetables, coffee, peanuts, potatoes, onions, and cereals.
Chlorothalonil, which has a broad spectrum of activity, is also used on turf, lawns, and ornamental plants, and in wood preservatives and anti-fouling paints. Particular attention is given to crop residue studies.

The most extensive section evaluates the results of toxicity studies conducted in laboratory mammals and in vitro test systems. Studies show that chlorothalonil has low acute oral and dermal toxicity; the main effects of repeated oral dosing are on the stomach and kidney. The evaluation gives particular attention to several feeding studies which demonstrated a rapid onset of toxic effects on the forestomach and kidney, and a rapid induction of forestomach and renal tumours in rodents, but not in other species, including the dog. Most studies failed to demonstrate mutagenicity; the limited data available indicate that the compound is not teratogenic and shows no reproductive toxicity.

Data on effects on human health are confined to case reports of contact dermatitis following occupational or accidental exposure. In interpreting the relevance of experimental findings to human health, particularly the evidence of carcinogenic potential in rodent models, the report notes important species differences in metabolic pathways and postulates that chlorothalonil probably exerts its carcinogenic effects in rodents via a non-genotoxic mechanism. Concerning effects on other organisms in the laboratory and field, the report cites evidence that chlorothalonil is highly toxic to fish and aquatic invertebrates in laboratory studies, but is not phytotoxic and should not pose a risk to wild mammals.
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