Yo Don't ask a Red Neck what kind of fuel mileage they are getting on their Pickem Up Truck. You will only get a very Blank look and a DUH response. Ask a compact owner and you get an answer to the hundreds of a mile. So the Question is WHAT KIND OF MPG DO YOU GET and ON WHAT ENGINE. Mine are. 2.5 Ranger gets 27 MPG 300 6 F 250 gets 14 MPG Isuzu NPR 135 hp gets 12 MPG Diesel I am looking to buy an other truck and put a 200 gallon Skid Sprayer in it. I believe the 4.3 V6 Chev gets the best gas mileage, But would like some input from those smart enough to operate a calculator and figure costs of driving. I want to replace the F 250 with a better mileage Truck. BTW I plan to buy used so I can pay cash. There are a few 3/4 ton 4.3 made but they are hard to find used because the run great and cheap. I will take a 1/2 ton. Please only reply about a truck you own or have owned.