Braking doesn’t affect fuel mileage, unless you are saying you eventually have to accelerate, which temporarily lowers economy.
The first rule in getting good gas mileage is to drive as if your brakes don’t work. It’s not the low speed limits that causes low gas mileage in urban driving, it’s the constant braking. If you can drive around town without touching your brakes, your city gas mileage will be higher.
Braking shaves off speed that took fuel to build.
We spend fuel to get up to speed, we spend it maintaining it too.
Fuel is consumed at a greater rate anytime our foot is on the gas.
If we let off the gas sooner we use less brakes, consume less fuel, and our tires last longer.
On a note, retarders, j-brakes and "smart" (or radar) cruise controls that like to activate brakes are not good for fuel economy either. Better to let off the gas sooner, even if that means falling below the speed limit.
Take it from someone who has taken vehicles from 10 to 15 mpg, trust me one thing, it's nothing that can be learned overnight... Takes years, decades really, decades of driving and paying attention to what is actually going on. However I seriously doubt a V10 pulling 12,000 pounds is going to see much of anything close to 16mpg.