"Both vinegar and 2,4D are acetic acid compounds." And my .01 one cent is that while they may both be acetic acid compounds it is what the 2,4-D comes along with that prevents one from saying they are "the same". While the bricks are similiar, the end product is different. Therefore the question misrepresenting the two products. Further the question involves an assumption that less acid is needed by using 2,4-D instead of vinegar. It sounds reasonable but it is still an "assumption". And the question involves a qualitative word "preferred". Preferred for what? Is it preferred by people adverse to chemicals? No. As Hamons wrote What is the best? "Best" according to what? "Preferred" according to what? If less acetic acid is you only criterion, then let's go there. If it is agreed less acid is better. Then the question is "is 2,4-d preferred for weed control?". I would say YES. 2,4-d is preferred for weed control it is probably more dependable and reliable than an equal amount acetic acid in a vinegar solution. AND IF weed control is the ONLY thing you are seeking you got a winner! HOWEVER, organic methods seek weed control while NOT compromising the overall environment. What is the "best" treatment. The answer depends on what the customer defines best. Best for my dog's health, best for the soil, best for my pocketbook, best for the color of green grass, best for my well water supply, best for the horse eating the grass, or best for my LCO to look good to the neighbors. ???? Let's reword it to "Is 2,4-D the preferred product over vinegar for the overall benefit of the environment?" No. While you might want a scientific study to confirm that, I would like to read a scientific study that says "2,4-D is preferred and less harmful to the environment than vinegar". I'm sure those will be right next to the "web pages saying DDT is not harmful". ***************** It can be generalized that if you have an intruder in your house it would be better if the intruder was short and small, so you might be more likely to kick his as, right. IF you assume a smaller person is easier to overpower, wouldn't a short burglar be better than a big one. IF the answer is yes, then Gary Coleman would be less of a threat than Arnold S.. Right? Unless of course Gary Coleman is packing a .357.