It depends on the rear end ratio, how fast your going, and how loaded/unloaded you are. If the 350 has a decent gear ratio, your not going to fast, and your unloaded, than you could expect some reasonable mileage out of it, but every truck is different. In the 450 and the 550 I wouldn't expect much mileage at all, most of them have 4.30 rear ends I would figure, not to mention the weight of them is against you as well. Honestly though, if your worried about fuel mileage in vehicles that big than I wouldn't look at them. If your buying one, fuel mileage is the last thing you take into consideration.