Yes and no. Consumer Reports did an article a while back on this. Gas is gas - until it's loaded in the tanker trucks, where brands have their own additive packages added. Their individual additive packages are what makes gas "branded". So there is some difference between between brands, but only in the additives they blend in. All gas must meet a minimum standard. Can't recall much more of the specifics of the article, but the gist was buy from a trusted retailer who sells lots of gas so you're less likely to have old, stale gas or gas that has been compromised by bad underground storage tanks. If you have a station that's convenient, competitively priced, you'll have to weigh the cost of driving further to justify a few pennies difference. So lets do the math. If we get 30 gallons of gas, a 2 cent difference is just 60 cents. 60 cents is about 1/5 of a gallon. At 10 mpg, driving about a mile furthe, then back, (2 miles total) would be the break even. Farther than that, it costs you more than your saving.